Our new research reveal that this is due to faulty trafficking of late endosomes to lysosomes, with concomitant homotypic fusion with the influenced vesicular compartments [five]. The defect in lysosome-directed trafficking also affects autophagic flux, with resultant accumulation of autophagosomes [five]. Ultimately, the integrity of your cell membrane is compromised https://clivet752kpt5.wikijournalist.com/user