TAK-243 preferentially certain to UBA1 over the similar E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 decreased levels of ubiquitylated proteins, increased markers of proteotoxic strain and DNA injury stress. In vivo, TAK-243 diminished leukemic load and qualified leukemic stem cells with no https://deanlfyp76554.theisblog.com/29208517/5-essential-elements-for-ponicidin