Chemotherapy was potentiated by E7449 and solitary agent had sizeable antitumor exercise in BRCA-deficient xenografts. Furthermore, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, probably by way of TNKS inhibition. Consistent with this possibility, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilization and noticeably altered expression of https://aaronb974otx6.blogofchange.com/profile