Opioid action is due to equally low affinity binding of your mum or dad compound and better affinity binding on the O-demethylated metabolite M1 to μ-opioid receptors. In animal types, M1 is up to 6 instances much more strong than tramadol in making analgesia and 200 times far more potent https://hamidv110bkq5.wikiadvocate.com/user