Gastrointestinal (GI): NSAIDs that block COX-one activity have correlations with GI complications mainly because of the inhibition with the synthesis of gastroprotective agents including PGE2 together with other prostaglandins. This inhibition leads to lessened mucin output by gastric epithelial cells, less bicarbonate secretion, and less epithelial cell turnover, amid other https://shigesatop163xdy4.mysticwiki.com/user