Environmental or self-antigens and homotypic interactions bring about BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other indicators in the microenvironment and expanding the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have determined recurrent mutations in genes regulating tumor mobile-microenvironment interactio... https://mitchb582krv1.gigswiki.com/user