Pentobarbital will lower the level or outcome of etravirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. pentobarbital will lower the extent or effect of itraconazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unknown. pentobarbital will lower the extent or result of alfuzosin by impacting hepatic/intestinal... https://francesh234cul7.wikifordummies.com/user